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Man who urinated up to 18 times a day says robot-assisted surgery changed his life

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Man who urinated up to 18 times a day says robot-assisted surgery changed his life


A father whose life was severely impacted by an enlarged prostate, causing him to urinate up to 18 times a day, has described a new robot-assisted surgery as a “significant improvement” to his quality of life.

Mark Oliver, a 67-year-old retired electrical engineer from Long Hanborough, West Oxfordshire, endured years of debilitating symptoms before undergoing the innovative procedure.

Mr Oliver first noticed symptoms of an enlarged prostate around 2016, at the age of 57. Initially, this manifested as interrupted sleep, requiring him to get up a couple of times during the night to use the toilet.

Mark’s prostate is the ‘size of an orange’ (Collect/PA Real Life)

Within two years, he observed a marked decline in his ability to control his bladder, prompting a visit to his doctor. While initial tests came back normal, further investigations revealed his prostate had grown to “the size of an orange” – significantly larger than the typical walnut-sized organ.

The condition led to regular, involuntary bladder leakage, forcing Mr Oliver to wear incontinence pads.

He was prescribed medication, tamsulosin, which offered only marginal relief by relaxing muscles around the prostate. At its worst, he was using the toilet “a dozen times” during the day and up to “six times a night,” leading to “pretty sad nights waking up tired and irritable.”

The constant struggle took a heavy toll on his mental well-being and social life.

Symptoms started with needing to use the toilet in the middle of the night
Symptoms started with needing to use the toilet in the middle of the night (Collect/PA Real Life)

“When I explain to people how big the improvement is – if normal activity in going to the loo is 100%, I was down to having probably 10% control,” Mr Oliver told PA Real Life.

He recalled the embarrassment of being “absolutely saturated” while playing golf, constantly searching for a bush, and being unable to concentrate on the game or company. “It was bringing on a little bit of depression and anxiety because it was in the forefront of my mind all the time,” he explained. “It made me go into a shell and not socialise.”

Public outings became a logistical challenge, with Mr Oliver planning his day around toilet access and even carrying a master key for disabled facilities.

He also noted that before identifying coffee and tea as triggers, he would frequently interrupt work meetings to use the lavatory, feeling “people looking” at him each time he got up.

His initial fears in 2016 were of prostate cancer, as his father had been diagnosed with the condition in his mid-70s. However, extensive investigations over the years, including blood tests, urine flow tests, kidney tests, abdomen MRI scans, and neurology appointments, all returned normal results.

He was ultimately diagnosed with Benign Prostatic Hyperplasia (BPH), the medical term for an enlarged prostate. Prostate Cancer UK states that BPH is very common in men over 50, with about one in three experiencing urinary symptoms, and importantly, it does not increase the risk of prostate cancer.

In 2021, aged 62, Mr Oliver’s doctor suggested a transurethral resection of the prostate (Turp) procedure, but it carried risks of side effects like erectile dysfunction and worsening incontinence.

Despite this, he found “light at the end of the tunnel” and joined a waiting list. By November 2024, still waiting, he received a call offering an alternative: aquablation therapy.

Mark was prescribed a medication called tamsulosin to help reduce the symptoms
Mark was prescribed a medication called tamsulosin to help reduce the symptoms (Collect/PA Real Life)

This minimally-invasive procedure uses a high-pressure water jet to remove excess prostate tissue, guided by a robot.

It is becoming increasingly available across the UK, offered in 13 NHS hospitals and nine Nuffield Health facilities. As an NHS patient, Mr Oliver received the treatment free of charge at The Manor Hospital in Oxford, a Nuffield Health hospital.

Though “a little bit apprehensive,” he proceeded with the two-hour procedure three weeks later.

Admitted under general anaesthetic, Mr Oliver described the removal of his catheter 24 hours post-surgery as the “most painful” part, though it lasted only “a minute or two.”

He praised the “incredible” care he received.

He underwent aquablation therapy at 66
He underwent aquablation therapy at 66 (Collect/PA Real Life)

Recovery was “painful, but not intolerable,” with no significant improvement for the first six weeks. However, within a year, his condition “significantly improved.” He now uses the toilet “two or three times at the most” during a normal day, a dramatic reduction from 18.

He still exercises caution with liquid intake, avoiding drinks after 7 pm and monitoring caffeine and alcohol, and continues to wear level one or two incontinence pads as a “psychological” precaution.

The most profound change has been his renewed confidence. Last week, he socialised with friends, an activity he would have avoided before the aquablation. Mr Oliver believes it is crucial for men to be open about their health issues and to get checked if they experience symptoms. “Men of my generation, we keep our personal stuff to ourselves and it can have severe consequences,” he urged. “So I think the more you can open up and talk about it, the more likely it is that more people’s lives will be saved.”

For more information about Aquablation therapy with Nuffield Health, visit their website at: https://www.nuffieldhealth.com/treatments/aquablation-therapy



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Robots beat humans in half marathon

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Robots beat humans in half marathon


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At the end of a half-marathon, runners are usually wiped out. That part looked normal in Beijing. What didn’t look so normal was who crossed the finish line first — a humanoid robot named Lightning.

While people slowed down and tried to catch their breath, the robots just stood there like nothing happened. No sweat. No fatigue.

And the gap was not small. The winning robot, built by Honor, finished in 50 minutes and 26 seconds. That beat the current human world record set by Jacob Kiplimo, who finished in 57 minutes and 20 seconds.

That is not a small improvement. It is a big jump.

HOW 432 ROBOTS ARE RELOCATING A 7,500-TON HISTORIC BUILDING

The winning humanoid robot crosses the finish line ahead of human runners, showing just how far this technology has come in a year. (CCTV)

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How humanoid robots went from struggling to record-breaking

This year tells a different story. Nearly half of the robots ran autonomously. No joystick. No remote operator guiding every step. They navigated the course on their own while running alongside human participants.

The event included more than 100 robot teams from 13 provinces, alongside about 12,000 human runners, showing how quickly this space is growing.

What matters more than the finish time is how they did it. Autonomy means these machines are starting to make real-time decisions in the real world. That is the same kind of challenge they would face in factories, warehouses or even homes. 

Why these humanoid robots are so fast

The winning robot, nicknamed Lightning, was engineered with a clear goal. Engineers gave it long legs designed to mimic elite human runners. The stride length and cadence were tuned for efficiency over distance.

They also borrowed technology from smartphones, including liquid cooling systems. That helped prevent overheating during sustained high-speed movement.

Sensors and onboard computing allowed the robot to adjust its balance and path in real time. That is a big deal. Running is controlled falling. Doing that at speed without crashing requires constant correction.

According to the engineers behind the project, the real goal is not racing. It is stress-testing systems. If a robot can run 13.1 miles at high speed without failing, it can likely handle long shifts in industrial settings without breaking down.

What the robot companies are actually saying

The teams behind these machines are not claiming robots will replace marathon runners. That would miss the point. Instead, they see events like this as a proving ground.

Engineers involved in the project say improvements in movement, cooling and structural durability will carry over into real-world uses. That includes manufacturing, logistics and potentially service roles.

In other words, the race is a demo. The real product is reliability. And reliability is what makes robots useful where people actually need them.

Why humanoid robots still struggle in real-world situations

Robot at race

Nearly half the robots ran on their own, navigating the course without human control, a big step toward real-world use. (CCTV)

For all the headlines, this was not flawless. One robot fell at the start. Another collided with a barrier. Those moments matter.

They show that even with record-breaking speed, humanoid robots still struggle with unexpected situations. Unexpected obstacles, sudden changes or minor errors can still cause failure.

That gap between peak performance and consistent performance is where humans still have an edge. For now.

Why this humanoid robot half-marathon is bigger than a race

It is easy to dismiss a robot race as a stunt. That would be a mistake. Running combines balance, endurance, decision-making and energy management. If robots are improving this quickly in one of the hardest physical tasks, progress in simpler tasks will move even faster.

We are already seeing robots carry groceries, assist in kitchens and handle repetitive cleaning tasks. Add mobility and endurance at this level, and their usefulness expands quickly.

This is how adoption happens. Quiet improvements, then sudden capability jumps that feel overnight.

What this means to you

You are not about to get outrun by a robot at your local 5K. But you are getting closer to a world where robots show up in more parts of your daily life.

Expect to see them in warehouses first, then in customer-facing roles where consistency matters more than personality. Over time, costs will drop, and capabilities will improve.

That affects jobs, convenience and even how services are delivered.

It also raises questions about safety, oversight and how much autonomy we are comfortable giving machines.

JOB-KILLING ROBOT LEARNS AT WORK, AND IT’S COMING TO THE FACTORY FLOOR

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Kurt’s key takeaways

A robot winning a half-marathon sounds like clickbait. But it is also a sign of where things are headed. Not because robots are faster, but because they are starting to run on their own in the real world. That is when this stops being interesting and starts becoming something you feel in your everyday life. Are you ready for a world where this is normal?

If robots keep improving at this pace, where do you draw the line between helpful automation and something that starts to replace too much of what humans do? Let us know by writing to us at Cyberguy.com.

Robot crossing finish line

Built for endurance, the robot uses long, human-like strides and cooling tech to keep running without overheating. (CCTV)

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Bad optics? Israel jails soldiers who smashed Jesus statue in Lebanon

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Bad optics? Israel jails soldiers who smashed Jesus statue in Lebanon


Footage of an Israeli soldier attacking a Christian statue depicting the crucifixion of Jesus in southern Lebanon with a sledgehammer was difficult for Israel’s political establishment to ignore. The country has long tried to frame itself as a defender of Christians, and is allied with the powerful Christian Zionist movement in the United States.

But as Israel continues to lose support in the US and the West for its genocidal war in Gaza and attacks in Lebanon and Iran, support among Christians has also dipped – even before the video of the desecration of the Christian statue surfaced.

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Responding to the footage on Monday, a day after it first went viral, Israeli Prime Minister Benjamin Netanyahu pushed his regularly repeated line that Israel respects all religions, even as critics point out that his government regularly does the opposite.

But, with even some of Israel’s supporters voicing anger at the soldier’s actions, Israel announced on Tuesday that he had been jailed for 30 days, along with another soldier who had been filming him. Six other soldiers have been summoned for questioning.

The decision to pursue action against the two soldiers stands out because it is in marked contrast to Israeli military investigations conducted into violations by soldiers, which overwhelmingly find them not to have been at fault. In fact, no Israeli soldier has been charged with killing a Palestinian this decade, despite the thousands killed even outside of the Gaza war context, including the 2022 killing of Al Jazeera’s correspondent in the occupied West Bank, Shireen Abu Akleh, who was herself a Christian.

Yossi Mekelberg, a senior consulting fellow with Chatham House, noted that it was important for the Israeli government to ensure that its response to the attack on the statue of Jesus was visible, particularly in light of the important role Christian supporters of Israel – including the US ambassador to Israel, Mike Huckabee – play in the administration of US President Donald Trump.

Those supporters frequently justify their support for Israel by relying on Christian Zionist interpretations of the Bible, and emphasising a “Judeo-Christian” value system and shared cultural heritage.

But official Israeli action in this case makes inaction in other cases more glaring.

“This [attack on the statue of Jesus], and the attacks upon mosques by settlers and the killing of Palestinians are all war crimes,” Mekelberg said. “The problem is that we don’t know how widespread it is. We only know about this one because they filmed it.”

History of violence

Through much of the conflicts in Gaza and Lebanon, observers and analysts have pointed to the stark difference in Israeli government responses to attacks on Christian symbols and places of worship and what has been the large-scale destruction of Islamic sites.

In March, Netanyahu found himself having to explain the decision to block the passage of Cardinal Pierbattista Pizzaballa, the Latin patriarch of Jerusalem, from entering the Church of the Holy Sepulchre to mark Palm Sunday, one of the holiest days of the Christian calendar. Before the end of the same day, Netanyahu had posted to social media, explaining that there had been “no malicious intent whatsoever, only concern for his safety”.

Last July, Netanyahu again found himself apologising for a strike on a third church in Gaza following pressure from the Trump administration, when three of the hundreds of people sheltering there were killed and several others injured, including the parish priest who regularly spoke to the late Pope Francis.

In a statement issued through his office, the Israeli prime minister claimed he deeply regretted the strike on the church, which he said was an accident.

“Every innocent life lost is a tragedy. We share the grief of the families and the faithful,” he said, without referencing the almost 60,000 men, women and Palestinian children his forces had killed by that point in the war.

Throughout the war, Israel’s defenders have emphasised the concept of Judeo-Christian values in an effort to justify Israel’s attacks and its repeated breaking of international law. But evidence of a shared civilisational bond is thrown into question by attacks on Christian symbolism, such as in Lebanon, and by Israel’s long-standing treatment of Palestinian Christians, who face the same dispossession and occupation as their Muslim neighbours.

“I think a lot of Israel’s defenders in the West like to portray it as being ‘us’, just over there, as if ‘over there’ is some form of dark jungle,” said HA Hellyer, a senior fellow at the Center for American Progress and senior associate fellow at the Royal United Service Institute.

“So, they can make excuses for Israelis killing Arabs in their thousands,” Hellyer said. “They can even make excuses for them killing Christians. But when you see Israeli soldiers destroying Christian symbols, it becomes much harder to defend those actions and to stem the growing trend of US supporters, both Democrat and Republican, moving away from Israel.”

What’s next for Israel’s relationship with Christians?

While the Israeli government has been keen to preserve evidence of the Judeo-Christian bond, complaints of harassment by Christian groups within Israel are growing, particularly with the increase in strength of the Israeli far right, including in government.

In 2025, the interreligious Rossing Center for Education and Dialogue recorded 155 incidents targeting Christians in Israel, a marked increase from the previous year. While physical assaults were the most common, comprising 39 percent of incidents, there were also accounts of spitting, hitting, and pepper-spraying.

Christian holidays, specifically those around the time of Easter, have become particular sources of tension, the report noted, with priests and nuns wearing visible Christian clothing in West Jerusalem and occupied East Jerusalem facing the risk of harassment every time they enter public spaces.

“We’ve entered a period of what [Australian genocide studies scholar] Dirk Moses called ‘permanent security’, where anything different, anything that might be a threat, or could even be a threat in the future, has to be destroyed,“ prominent Israeli sociologist Yehouda Shenhav-Shahrabani told Al Jazeera.

That difference is inherent to the Christian faith.

“It’s not about left or right,” Shenhav-Shahrabani explained. “It even goes to language. In everyday Hebrew, people refer to Jesus as Yeshu, which is a curse word, rather than Yeshua, which is correct.”

“That’s commonplace. That’s how it’s used in everyday media,” he continued. “If that’s where you begin, it doesn’t matter if it’s stupidity or ignorance, it all leads to the same place.”



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Royal Mail pension scheme contract terminated after ‘failure to deliver milestones’

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Royal Mail pension scheme contract terminated after ‘failure to deliver milestones’


The contract for the new Royal Mail statutory pension scheme with Capita has been terminated, a Cabinet Office minister confirmed, after the services group “failed to deliver numerous milestones”.

Speaking in the Commons, Nick Thomas-Symonds stated the government had repeatedly flagged Capita’s delays.

He pledged it “will not hesitate to act decisively” to protect public servants’ pensions, assuring Royal Mail pensioners of efforts “to ensure continuity of service”.

In a statement, Mr Thomas-Symonds said: “Following a failure to meet critical transition milestones and a lack of confidence in Capita’s ability to implement and transition to the new operating model in a timely fashion, I’m announcing today to the House that I have terminated the new Royal Mail statutory pension scheme contract with Capita.

“Capita had an 18-month planning window to prepare for the transition. They failed to deliver numerous milestones, including a failure to implement the required IT automation.

“The Cabinet Office repeatedly flagged delays in transition milestones.”

He added: “The security and dignity of those who have dedicated their careers to our public services are not negotiable, and they deserve a pension service that is reliable, efficient and secure.

“But for these principles to be more than just words, they need to be underpinned by rigorous accountability and refusal to accept second best.”

Capita has come under fire in recent months for its management of pension services, with some members of the Civil Service Pension Scheme (CSPS) failing to receive regular payments after the company took it over in December.

Mr Thomas-Symonds told the Commons on Wednesday that assurances given to his department by the head of Capita over the CSPS have not been met, branding the financial impact on members “unacceptable”.

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Cabinet Office minister Nick Thomas-Symonds
Cabinet Office minister Nick Thomas-Symonds (PA)

The minister added that he, along with the permanent secretary of the Cabinet Office, had discussed the takeover of the pension scheme.

Capita has a backlog of 24,000 outstanding pension quotations and 1,500 unresolved complaints by MPs, a situation Mr Thomas-Symonds branded “totally unacceptable”.

The Government has already provided £7.2 million in interest-free transitional support loans to more than 1,300 members.

Mr Thomas-Symonds said: “We sought and were given explicit personal assurances that the transition would be handled with the utmost care and that any backlogs would be managed effectively.

“I’m sorry to say those assurances have not been met.

“It is clear in any event that the delivery of the service to civil servants since the transfer on December 1 last year has fallen far short of the required standard.”

He added: “I want to say that the stories we have heard of members missing mortgage payments and falling into hardship are distressing and entirely unacceptable.

“No-one should have to face such financial anxiety after a lifetime of dedicated public service.”

The minister also said a breach of the CSPS members’ data in late March was a “fundamental failure in data protection” and the Information Commissioner’s Office (ICO) has been informed, while the Cabinet Office has written to the chief executive of Capita to demand an account of the failure.

The Government is also withholding “milestone payments” where targets have not been met.

He added: “The Cabinet Office has mandated a clear recovery target.

“Capita must clear all inherited arrears by the end of this month and restore service levels to standard, contractually required levels by the end of June this year.”

Mr Thomas-Symonds assured Royal Mail pensioners the Government “will do all we can … to ensure continuity of service”
Mr Thomas-Symonds assured Royal Mail pensioners the Government “will do all we can … to ensure continuity of service” (PA)

Capita took over the CSPS, which manages the pensions of 1.7 million public sector workers in the UK, including institutions such as the Crown Prosecution Service, HM Revenue and Customs and the Ministry of Defence, in a seven-year deal in December.

In January, Capita told the BBC it had expected a backlog of 37,000 cases when it took over the scheme, but the number of outstanding cases was 86,000.

By February, the Government announced a recovery plan to address the “unacceptable service levels” experienced by members, including a support loan scheme for those experiencing hardship.

Mr Thomas-Symonds told MPs on Wednesday that Capita has offered to cover the costs of a circa-140 person Government surge team sent in to bolster operational capacity, which he said he is considering.

“My priority is for taxpayers to not have to foot the bill for issues that have been caused by the provider, and is of no fault of the people who are the beneficiaries of this scheme,” he added.

John McDonnell, Labour MP for Hayes and Harlington, said: “It shouldn’t be an offer. It should be a requirement that they cover the cost of the recovery costs.”

The former shadow chancellor under Jeremy Corbyn urged the Government to terminate the CSPS contract with Capita and to transfer the service “in-house”.

This was also called for by Labour’s Clive Betts, deputy chairman of the Public Accounts Committee, who argued this could “prevent these recurring problems with a variety of private sector providers, which always seem to go wrong”.

Mr Thomas-Symonds said he keeps “all contractual options open”.

He added: “I will not hesitate to use the commercial levers that are under this contract to drive performance. That is why I am being as well, absolutely clear about that restoration of service by the end of June of this year, that is what I am upholding Capita to.”

Unite national officer Dominic Hook said: “Once again, Capita has proved itself to be totally unfit to manage the pensions of millions of public sector workers.

“This latest in a litany of extremely serious failures by Capita shows why the Government’s manifesto promise to reverse outsourcing is more important than ever. Ministers need to keep that promise by bringing the CSPS back in-house.”

Steve Thomas, deputy general secretary of the Prospect union, said it was becoming clear that outsourcing pensions contracts has been a “catastrophic failure” which should be reviewed.

“It is right that Capita are facing consequences for failing to hit their targets but if they continue to not deliver as promised then the contract should be removed from them,” he said.

A spokeswoman for Capita said: “Capita has administered the Royal Mail statutory pension scheme since 2018, and we will continue to support its 337,000 members during the transition period, working closely with the Cabinet Office to ensure continuity of service for members.

“We are very sorry for the serious issues that have been raised regarding our performance on the Civil Service Pension Scheme and the impact on its 1.7 million members.

“We recognise the distress this has caused and the strength of feeling being expressed.

“We take full responsibility for addressing these issues. Our focus is on ensuring members receive the service they expect and deserve, and on putting things right as quickly as possible.”



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Called out ‘kallo, kali’: Meet Hema Gill, ‘that terrace girl’, who shattered trolls with her impeccable terrace walk and landed a Guru Randhawa video | – The Times of India

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Called out ‘kallo, kali’: Meet Hema Gill, ‘that terrace girl’, who shattered trolls with her impeccable terrace walk and landed a Guru Randhawa video | – The Times of India


Hema Gill, the “terrace video girl,” defied narrow beauty standards in India by embracing her dusky skin and confidence. Rejected for modeling due to her height and skin tone, she created her own runway online. Her viral terrace walks led to brand deals and a music video with Guru Randhawa, proving self-belief can challenge societal norms.

Social media has the power to make or break the dreams that people set for themselves.Content creators often post photos and videos that turn them into overnight sensations – but, like a coin with two sides, sharing multimedia online comes with its own set of risks.But one girl has challenged these norms, coming back stronger – proudly owning herself with complete confidence and fighting back at the people who questioned her choice.Meet Hema Gill, popularly known online as the “terrace video girl.” Her journey isn’t just about going viral or stepping into a music video with Guru Randhawa – it’s about a young woman refusing to let narrow beauty standards define her worth.

Called out 'kallo, kali' Meet Hema Gill, 'that terrace girl', who shattered trolls with her impeccable terrace walk and landed a Guru Randhawa video

Photo: @the_hemagill/ Instagram

Indians have long been fed the stereotype that “fair-skinned equals beautiful,” but Hema’s dusky skin and unapologetic confidence have become a quiet rebellion. She was told she didn’t fit the mould of a model, but instead of shrinking, she built her own stage right on the terrace of her home.

Who is Hema Gill?

From “won’t fit the bill” to finding her runwayHema Gill is an online content creator, known for her terrace ramp walk videos that often go viral, earning her millions on views.She studied fashion in Delhi and landed a job, however she did not feel satisfied with her role and decided to quit.According to her interview with Brut, she faced rejections in modelling roles for her height but she decided to frame her own runway.According to Indiatimes, “Hema Gill was told she didn’t ‘fit the bill’ to be a model. So she built her own stage.” Instead of giving up, she started posting videos online, all dressed up performing rampwalks with utter confidence and impeccable moves.Spending hours observing catwalk videos, copying posture, and rehearsing expressions until walking in front of the camera felt like second nature.Initially, her clips were raw and unpolished, but they carried a clarity that filters and fancy studios often drown out: she believed she belonged on the runway, even when no one had invited her.

She faced rascism for her skin colour

She recalled in a Brut interview that neighbours called her out for her skin colour, with bizarre names like, ‘kali, kallo.’ She even ended up picking fights with her neighbours who called her out for alleged nudity, pulling down a sticker from her room wall when asked what exactly she was doing wrong.

From rooftop clips to Guru Randhawa’s music video

The turning point came when one of her terrace walks went viral, amassing millions of views and sparking a wave of both praise and criticism.Her growing online presence led to brand partnerships and appearances in projects produced by big names in the entertainment industry, including a feature in the song “Vogue” produced by Bhushan Kumar. This momentum eventually caught the eye of singer Guru Randhawa, leading to a music‑video collaboration that marked a major milestone in her modelling journey.

Challenging beauty standards, one walk at a time

Hema’s story is not just about personal success; it is about how a single, stubborn act of self‑belief can chip away at long‑held beauty norms. In one of her own Instagram reels, she reflects on being called “too dark” as a child, writing, “At five, I dreamed of runways. At auditions, my skin spoke for me.” Even when someone from a nearby building shouted “kali” during one of her terrace shoots, instead of hiding, she recorded the moment and chose to own it, turning shame into narrative.



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EU approves €90bn loan for Ukraine as pipeline is turned on ending deadlock

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EU approves €90bn loan for Ukraine as pipeline is turned on ending deadlock


Slovak Economy Minister Denisa Sakova said she had been told by energy operator Ukrtransnaft, which looks after the Druzhba pipeline in Ukraine, that pressurising of the pipeline had begun on Wednesday morning and crude oil would start flowing into Slovakia on Thursday, for the first time since 27 January.



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Natural hormone may reduce obesity without cutting calories, scientists say

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Natural hormone may reduce obesity without cutting calories, scientists say


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Researchers at the University of Oklahoma have discovered a hormone that appears to reverse obesity in the body.

The new study, published in the journal Cell Reports, used mouse models to identify a naturally occurring hormone called FGF21 (fibroblast growth factor 21).

The hormone “appears to work by signaling to a brain region involved in metabolism and appetite regulation, the same area targeted by the popular GLP-1 drugs,” according to a university press release.

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FGF21 is reportedly already involved in the development of a drug to treat metabolic dysfunction-associated steatohepatitis (MASH), which is a form of fatty liver disease.

Lead study author Matthew Potthoff, PhD, a professor of biochemistry and physiology at OU College of Medicine and deputy director of the OU Health Harold Hamm Diabetes Center, said the study showed how the hormone sends “signals” to the lower back region of the brain.

Close up of unrecognisable woman in orange sport clothes measure weight on scale at home. (iStock)

“In our previous studies, we found that FGF21 signals to the brain instead of the liver, but we didn’t know where in the brain,” he wrote.

“We thought we would find that it signaled to the hypothalamus (which is widely implicated in body weight regulation), so we were very surprised to discover that the signal was to the hindbrain, which is where the GLP-1 analogs are believed to act.”

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The brain circuit behind these metabolic benefits appears to work by “mediating the effects of FGF21,” Potthoff said — a process that can also be linked to side effects like gastrointestinal issues and, in some cases, bone loss.

“We hope that by identifying the specific circuit, it can help in the creation of more targeted therapies that are effective without negative side effects,” he added.

Doctor holding an MRI scan of a brain while consulting an elderly woman

According to the study, the hormone “appears to work by signaling to a brain region involved in metabolism and appetite regulation, the same area targeted by the popular GLP-1 drugs.” (iStock)

The FGF21 and GLP-1 hormones act differently, although they target the same area of the brain, according to the researchers. While GLP-1 reduces food intake via appetite, FGF21 increases metabolic rate, burning energy and triggering weight loss.

Potthoff shared his hope for a new FGF21 drug that could target both weight loss and MASH, noting that additional studies are necessary to explore this potential.

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Dr. Peter Balazs MD, a hormone and weight loss specialist practicing in New York and New Jersey, said this discovery raises the possibility of targeting metabolic rate “directly,” rather than relying only on calorie restriction.

“However, this is a preclinical [mouse] study using diet-induced obesity models, which is not fully relevant or similar to human obesity’s chronic metabolic adaptations,” he told Fox News Digital.

Woman weighing herself on a scale in a bathroom

“The study is a nice first step toward alternative biochemical pathways for treating obesity,” a hormone expert commented. (iStock)

FGF21 behaves differently in humans than in mice, as obese people have higher levels of the hormone in their blood, according to Balazs. This raises the question of how effective FGF21-based treatments would be.

“There are also important clinical concerns, such as whether FGF21 analogs can cause side effects like digestive issues and bone loss, which is especially risky since obesity already increases the chance of fractures,” he cautioned. “The study doesn’t explain how these issues might be managed.”

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Early human trials of FGF21 showed “modest weight loss” between 5% and 8%, according to Balazs, which is “less impressive” compared to GLP-1 treatments’ average 15% weight loss.

It is also unclear whether the body could develop tolerance to FGF21 over time, which could reduce its effectiveness with long-term use, he added.

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“The study is a nice first step toward alternative biochemical pathways for treating obesity,” Balazs added. “However, clinical adoption will require safety trials that include bone density monitoring, along with confirmatory data in humans.”



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Four arrested over suspected home insulation scheme fraud

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Four arrested over suspected home insulation scheme fraud


He said the “sheer amount of money” that may have been fraudulently claimed, estimated at £44m, “serves only to underline further that the known levels of fraud in the scheme, as our committee warned earlier in the year, must be being significantly underestimated”.



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Brazil’s 80-year-old Lula hits the treadmill to ease voter concerns about age

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Brazil’s 80-year-old Lula hits the treadmill to ease voter concerns about age


SAO PAULO — Fewer podiums and interviews. More lunges and squats.

Brazil’s President Luiz Inácio Lula da Silva is pumping up his reelection bid at age 80 by looking jacked in workouts that his critics say are more popular than the man himself.

While Brazilians are divided over whether he should run for his fourth nonconsecutive term, there is a rare consensus regarding his commitment to run on a treadmill every day.

“He is a bit too old to campaign again. We’d better have someone else running. But his workouts are indeed a good example for people like me,” said Marcela Peres, 63, as she exercised in a hotel gym in Brasilia on Wednesday.

Lula’s attempt to show himself full of energy has led his main rival, Sen. Flávio Bolsonaro, a son of former President Jair Bolsonaro, to show his moves too.

Some voters have expressed concern that Lula might follow the path of former U.S. President Joe Biden, who withdrew from the 2024 race over questions about his health and age. But Lula is flexing his muscles to challenge supporters to stick with him again.

“One of these idiots said it was not me, that it was a clone,” Lula said in March, days after his wife, Rosângela da Silva, posted a video of his workout routine. “Go to the gym. Get ready. Drink less and work to see what happens. I want to live 120 years.”

The president frequently played soccer during his first two terms, maintained a workout regimen throughout his 580 days in prison and has advocated for exercise since he ran in 2022 to beat then-incumbent Bolsonaro, a former Army captain in poor health.

If Lula wins in October, he will beat his own record as the oldest man to be elected Brazilian president.

His main rival is almost half his age.

Bolsonaro, the 45-year-old son of the former president, recently mocked Lula by comparing him with an old Chevrolet Opala that is “all backward” and “drinks a lot (of fuel).”

Lula, who has appeared on nearly every presidential ballot since the end of the military dictatorship in 1985, brushed off the insult by describing himself instead as a “turbo car.”

“He is doing this to steer away from the Joe Biden effect,” said Carlos Melo, a political science professor at Insper university in Sao Paulo. “Flávio Bolsonaro is trying to say he is actually the young one. This is a game of image.”

The younger Bolsonaro is also signaling he is in good shape by sharing films of him in short races to meetings and dancing on stage.

This side of his personality became evident only in December, when his father anointed him as presidential candidate from prison in the capital, Brasilia, where he was serving a 27-year sentence for leading a coup attempt before moving to house arrest.

Consultant Felipe Soutello, who ran several campaigns for politicians in Brazil, said today’s bids for public office must feature candidates in motion, regardless of age.

“The opposition will use a certain ageism, a little prejudice against older generations, as a tool to hurt the president’s performance,” Soutello said.

But he noted that Brazil is undergoing a demographic shift, where voters above age 60 represent one fourth of the electorate. “They have more political weight than the young people,” he said.

The number of Brazilians above age 60 who are eligible to vote grew from 20.8 million in 2010 to 36.2 million in March of this year, according to researcher Nexus, citing figures of Brazil’s top electoral court.

Musician Antonio Moreira, 50, loves workouts on the beach in Rio de Janeiro, showing off his muscles, his tan and his tattoos. He is part of a small, influential group that could decide the election: voters still uncommitted to either Lula or Bolsonaro.

In the last election, Lula won with just 50.9% of the vote, the narrowest margin in the country’s history.

”Nobody wants to vote for a president that is stumbling,” Moreira said, adding that Lula’s workouts also encourage older people to stay active.

As for Bolsonaro’s moves, Moreira said “a little dance can define an entire political career” in Brazil. But that’s not enough.

“It is okay to do it as they do to seek for votes, but to reach a different kind of voter there needs to be more real proposals, right?”

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AP journalist Lucas Dumphreys contributed to this report from Rio de Janeiro.



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Your pint could come with a surprising health benefit

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Your pint could come with a surprising health benefit



Beer provides “substantial levels” of vitamin B6 into your diet, according to new research.



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