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Here are the college majors that new grads regret the most, according to a recent survey

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Here are the college majors that new grads regret the most, according to a recent survey


A college degree is often seen as a way to get a leg up in the labor market, which has recently been challenging for early-career workers. But as new grads begin their job searches, many say they wish they had chosen a different field of study.

Roughly one in five recent grads regret their major, according to a recent report from ZipRecruiter, which surveyed 1,500 graduates from the class of 2025, and another 1,500 students set to graduate this spring. Liberal arts majors were most likely to regret the area they chose to focus their studies, with many wishing they had pursued a scientific or quantitative field, according to the job site.

The fields with the highest share of regret among recent grads are political science, international relations, or public policy, with 46.3% of those majors expressing dissatisfaction with their choice, ZipRecruiter found. That’s followed by communications, media studies or public relations majors, 39.2% of whom said they rue their decision.

To be sure, it’s not only liberal arts grads who have second thoughts about their majors, with one-third of physical sciences majors — people who majored in physics, chemistry or earth sciences — expressing doubts, the analysis found. Regret may be more acute for young grads due to the stress of securing a career foothold, with research from the Federal Reserve finding that middle-aged workers are generally more positive about the value of their college degrees than younger Americans.

Many young workers are struggling to land roles in the current workforce amid a broad decline in job openings. Entry-level roles accounted for 38.6% of postings on ZipRecruiter as of March 1, down from 43.4% two years ago. These jobs are shrinking at the same time demand for those positions is increasing, the ZipRecruiter study shows.

Finding a job isn’t the only obstacle early-career entrants face. As recent grads enter the workforce, they may also bump up against the unfortunate reality that the jobs in their field pay less than they anticipated. 

For those who studied public health or health administration, the pay they received upon landing a job was 43.8% lower than they expected, ZipRecruiter’s survey reveals. Among agriculture, environmental science, or natural resources majors as well as English, literature, or journalism majors, compensation was 30% lower than they expected.

Nursing degrees pay off

For those worried about career prospects, studying nursing could provide a more secure pathway to employment, the study suggests.

ZipRecruiter found that nearly one-third of nursing graduates secured a job before graduation. Health care workers remain in high demand, especially as an aging U.S. population drives a need for care. The sector continues to drive employment growth: Health care jobs accounted for 43% of the total payroll gains in March.

Nursing majors also stand to benefit from higher pay. According to ZipRecruiter’s report, those who studied nursing landed the highest median salary upon graduation compared to other majors, at $70,000 a year.



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Hamas influence looms over Gaza elections as experts warn vote could backfire

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Hamas influence looms over Gaza elections as experts warn vote could backfire


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On Saturday, Gazans in Deir al-Balah will go to the polls to elect new local leaders for the first time in 2o years, a move experts warn could allow Hamas room to maintain influence as it refuses to comply with ceasefire disarmament terms.

The Foundation for Defense of Democracies Executive Director Jonathan Schanzer told Fox News Digital that “when you hold elections in the Palestinian Authority and the timing’s not right and the circumstances are still dicey, you get Hamas victories.”

Schanzer said the Bush administration’s 2006 decision to advocate for elections “led to Hamas winning, and it led to a standoff which led to a civil war.” 

“You’ve got to be really careful when it comes to holding elections with a territory like Gaza in particular, where Hamas has so much control, and where terrorist organizations are still considered to be legitimate players,” Schanzer added. 

EXPERTS URGE TRUMP TO BAN TERROR-LINKED UN AGENCY FROM HIS GAZA PEACE PLAN

Gazan journalists and media personnel continue to be posthumously identified as members of terrorist groups, highlighting the difficulty of distinguishing terror affiliates from civilians.

Election campaign banners showing candidates for the upcoming municipal elections hang on a building in Deir al-Balah in the central Gaza Strip April 21, 2026. (Eyad Baba/AFP via Getty Images)

Four parties are contesting the election in Deir al-Balah. To be eligible, candidates were asked to accept the Palestine Liberation Organization and the terms of agreements it has previously made, including recognition of the State of Israel and endorsement of a two-state solution, according to reporting by the Center for Peace Communications.

However, many are concerned that one party, Deir al-Balah Unites Us, is affiliated with Hamas. Two of its candidates have been pictured with Hamas officials or police officers.

Ahmed Fouad Alkhatib, resident senior fellow at the Atlantic Council, posted on X that “holding elections in Gaza at this time is extremely reckless and irresponsible,” noting that “Gazans are being arrested, jailed, tortured, shot, and killed daily for social media posts and anything they say that’s perceived as being critical of Hamas. 

“These elections should be halted and prevented from proceeding, for they are meddling with the transition process that the Board of Peace, [National Council for the Administration of Gaza], and the international community have planned for Gaza, with Hamas’s disarmament and relinquishment of power being the first necessary step.”

TRUMP SAYS ‘REAL CHANCE FOR GREATNESS’ AS NETANYAHU WHITE HOUSE MEETING LOOMS FOR GAZA TALKS

Disarmament of Hamas, a key demand within the second phase of President Donald Trump’s ceasefire agreement, has yet to be completed. Reports indicate that Hamas has increased its hold in Gaza as of March, continuing to tax locals, building education system and placing police throughout the territory it holds.

Hamas terrorists standing guard with weapons in Rafah southern Gaza Strip

Hamas terrorists stand guard in Rafah in the southern Gaza Strip Feb. 22, 2025, during the handover of hostages as part of a ceasefire and hostage-prisoner swap deal with Israel. (Hatem Khaled/Reuters)

Schanzer said Hamas is unlikely to hand over its arms. If it were to do so, he said that they “will try to make distinctions between weapons,” possibly offering to give up heavy weapons like RPGs while maintaining a large arsenal of automatic weapons.

Hamas appears to have made a partial disarmament offer. The New York Times reported April 19 that two Hamas officials said they would hand over thousands of weapons from their police force and other security institutions. The officials “did not provide a clear answer” when asked if weapons from Hamas’ so-called military wing would be included.

HAMAS FACES ‘LEGITIMACY CRISIS’ AS DESPERATE GAZANS FLOCK TO US-BACKED AID CENTERS

U.S. President Donald Trump holding a signed agreement at a summit in Sharm El-Sheikh Egypt

President Donald Trump holds up a signed agreement during a world leaders summit focused on ending the Gaza war in Sharm el-Sheikh, Egypt, on Oct. 13. (Suzanne Plunkett/Getty Images)

Schanzer pushed back on claims that Hamas’ political and military wings operate separately. 

“That is a fiction. The idea that they are separate in any way or that there is a firewall between them is asinine.” He said that this is “a distinction that has been made up by the West in order to be able to have political relations with Hamas, or to justify elections. It’s a mistake to buy into that fiction.”

Schanzer said weakening Iran could be key to minimizing Hamas’ influence. 

“The psychological impact of their top patron being defeated on the battlefield, I can’t overstate how important that event could be,” he said. “It would be a gut punch to Hamas.”

Gaza local elections.

An election campaign starts in the city of Deir al-Balah, Gaza on April 12, 2026, as part of the local elections scheduled for April 25. (Mohammed Eslayeh/Anadolu via Getty Images)

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With Israel controlling about 53% of the Gaza Strip and Hamas the remaining 47%, Schanzer said, “We could continue to see the erosion of Hamas control” amid the “slow and steady process of Israel winning on the ground.” 

He said patience, though, is necessary, adding that “the enemies of the United States and Israel and the West have a very different timeline. They want to wait out everybody because they know that we’d like to move on.”

The Trump administration did not respond to Fox News Digital’s questions about whether a partial disarmament would satisfy its ceasefire terms or if it would take action to stall elections until there’s more stability in Gaza



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Trader Joe’s customers sue over coffee’s caffeine levels

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Trader Joe’s customers sue over coffee’s caffeine levels


Some Trader Joe’s coffee drinkers are angry they didn’t get their caffeine fix, according to a new lawsuit filed against the retailer. 

Customers allege in a class-action lawsuit filed in California on Thursday that Trader Joe’s deceptively advertised its French Roast Low Acid whole bean coffee, leading them to believe it contained more caffeine than it did.

Four plaintiffs who purchased the Trader Joe’s coffee product, sold at the retailer’s stores across the country, allege the grocer failed to disclose that the product contained less caffeine than typical coffee products. 

Plaintiffs allege Trader Joe’s falsely advertised its coffee by not indicating low caffeine content.

Trader Joe’s


It is common practice, attorneys for the plaintiffs claim, to indicate a coffee product’s caffeine content only when “some process is used to reduce the amount of caffeine contained therein.”

“For example, full caffeinated coffee does not have any special labeling denoting that it is fully caffeinated, but ‘decaf’ and ‘half-caff’ coffees are labelled as such,” the suit states. 

While testing shows that the French Roast Low Acid coffee contained half the caffeine of a regular blend, it was not labeled accordingly, the suit claims, leading consumers to “purchase the product believing that it is fully caffeinated when it is not.”

Trader Joe’s did not immediately respond to CBS News’ request for comment on the lawsuit. 

Seeking damages

The suit claims that consumers rely on caffeine to fuel their work and personal lives. 

“It is so common that it is now cliché that coffee drinkers depend on the caffeine contained therein to provide them with the energy they need to get through the day. Accordingly, the amount of caffeine in a coffee blend affects a consumer’s purchasing decision,” the suit states.

A low-caffeine drink would not suffice for regular coffee drinkers, it adds. If they did choose to purchase a “half-caff” product, they would pay less for it, the lawsuit states.

Plaintiffs are seeking damages and for Trader Joe’s to stop selling the product through misleading marketing, according to the lawsuit.



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Women’s Six Nations 2026: Confident Ireland chase historic win in France

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Women’s Six Nations 2026: Confident Ireland chase historic win in France


France: Barrat; Grando, Rousset, T Feleu, Murie; Arbez, Bourdon Sansus; Mwayembe, Lazarko, Khalfaoui, Zago, Fall Raclot, Berthoumieu, M Feleu (capt), Champon.

Replacements: Riffonneau, Brosseau, Bernadou, Correa, Soqeta, Escudero, Chambon, Queyroi.

Ireland: Flood; Parsons, Dalton, McGillivray, O’Connor; O’Brien, Lane; Perry, Moloney-MacDonald, Djougang, Wall, Tuite, Hogan, King (capt), Wafer.

Replacements: Jones, O’Dowd, Cahill, Campbell, Monaghan, Whelan, Higgins, McGann.



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US targets China refinery in sweeping Iran oil crackdown, sanctions ‘shadow fleet’ tankers

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US targets China refinery in sweeping Iran oil crackdown, sanctions ‘shadow fleet’ tankers


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The U.S. Treasury’s Office of Foreign Assets Control (OFAC) on Friday sanctioned a major Chinese oil refinery and dozens of ships tied to Iran‘s “shadow fleet,” escalating efforts to choke off Tehran’s main source of revenue.

Officials said in a press release that the move targets Hengli Petrochemical, one of Iran’s largest oil buyers, along with a network of shipping companies and tankers responsible for transporting billions of dollars’ worth of petroleum products to foreign markets. The Treasury Department identified these “shadow fleet” vessels as the financial lifeline for Iran’s “unstable regime.”

The crackdown is part of “Economic Fury,” a broader campaign to squeeze Iran’s economy by limiting its ability to sell oil abroad, revenue the U.S. says funds the regime’s military and destabilizing activities across the Middle East.

“Economic Fury is imposing a financial stranglehold on the Iranian regime, hampering its aggression in the Middle East, and helping to curtail its nuclear ambitions,” Treasury Secretary Scott Bessent said.

SECOND TANKER SEIZED NEAR VENEZUELA AS US ENFORCES OIL BLOCKADE

An oil tanker is seen near the terminal at Kharg Island, Iran, as U.S. officials and analysts consider whether seizing the island could significantly impact Iran’s oil exports. (Ali Mohammadi/Bloomberg via Getty Images)

Hengli Petrochemical (Dalian) Refinery Co. is a China-based “teapot” refinery, a term used for independent facilities known for purchasing discounted crude, including from sanctioned countries.

The refinery, one of China’s largest independent facilities, has received Iranian oil cargoes from sanctioned shadow fleet vessels since at least 2023. Hengli has also purchased oil tied to Iran’s armed forces, generating hundreds of millions of dollars for the Iranian military.

Hengli has also received shipments tied to Sepehr Energy Jahan Nama Pars Company, a firm identified by U.S. officials as a front for Iran’s armed forces that helps facilitate oil sales abroad. The company operates on behalf of Iran’s Armed Forces General Staff, using a network of intermediaries and vessels to move sanctioned crude, with proceeds helping fund the country’s military programs and regional proxy groups.

IRAN’S REMAINING WEAPONS: HOW TEHRAN CAN STILL DISRUPT THE STRAIT OF HORMUZ

The Iranian-flagged Touska cargo ship pours smoke out of its engine room

The Iranian-flagged Touska cargo ship pours smoke out after U.S. forces launched missiles at it’s control room following its violation of the U.S. blockade in the Strait of Hormuz. 4/20/26. U.S. Central Command (CENTCOM) (U.S. Central Command (CENTCOM))

The new sanctions also target the network that makes these oil sales possible, a “shadow fleet” of aging tankers and shell companies that move petroleum across global markets while evading sanctions and obscuring the origin of shipments.

These ships avoid detection by transferring cargo from one tanker to another in the open ocean. Treasury officials said 19 vessels were targeted in the action.

A white U.S. military helicopter hovers over the bright orange sanctioned stateless crude oil tanker M/T Tifani during an U.S. interdiction.

A U.S. military helicopter hovers over the sanctioned stateless crude oil tanker M/T Tifani during an interdiction on April 21, 2026. (Department of War)

The move is part of the Trump administration’s renewed “maximum pressure” campaign against Iran, aimed at cutting off the regime’s primary source of revenue through oil exports and sanctions enforcement.

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U.S. officials say oil exports remain the backbone of Iran’s economy, and efforts to restrict those flows are designed to limit the government’s ability to fund its military, support proxy groups and advance its nuclear program.

Treasury officials warned that additional sanctions are likely as the U.S. continues targeting the networks, intermediaries and buyers that enable Iran to move oil on the global market.



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AI smart glasses will help visually impaired runners take on the London Marathon

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AI smart glasses will help visually impaired runners take on the London Marathon


LONDON — Running past Buckingham Palace during training, Tilly Dowler is closing in on a goal she once thought out of reach.

Dowler, who has Stargardt disease and says she has about 10% useful vision, only began running last year, starting with a couch to 5K program before building up to marathon distance. She is now preparing to run the London Marathon with her boyfriend as her guide, using AI powered Oakley Meta Vanguard smart glasses to help her navigate and track her progress.

“They are AI assisted,” she said. “While running, I can ask for live cues, such as what landmarks are around me and how far I have run.”

She said the glasses allow her to combine audio feedback with guidance from her running partner.

“I can put my music on but still be able to listen to my guide runner,” she said.

Her goal is not focused on speed.

“My mission was to inspire other people with sight loss and people going through something really tough and inspire them to believe in themselves,” she said.

Dowler is among a growing number of visually impaired runners using AI enabled smart glasses. These wearable devices combine standard consumer products with cameras, microphones and open ear speakers. They can be controlled with your voice, buttons or some simple gestures and use artificial intelligence to interpret surroundings and provide audio feedback.

The most well known smart glasses are from tech company Meta, which makes them in partnership with Ray-Ban and Oakley. More than 7 million pairs of Meta Ray-Bans were sold last year, underscoring their growing popularity. But they’ve also stirred privacy worries, including being used to film people without their knowledge as well as concerns that Meta was sending the video to human reviewers for AI training.

For Sha Khan, who lost around 90 percent of his vision in 2021 due to retinitis pigmentosa and Stargardt disease, the technology has become part of daily life as well as training.

“It’s like literally a part of me now,” he said. “If I step out the front door, I wouldn’t do that without my glasses on.”

Khan also relies on his guide dog, Moby, in his day to day life, using him for navigation outside of running.

He said the hands free nature of the glasses is especially useful because it allows him to stay focused on working with Moby without needing to handle a phone.

Khan began running in 2022 after a volunteer from Guide Dogs UK, a charity that provides guide dogs and mobility support for people with vision loss, encouraged him to try it after his sudden loss of sight loss and the impact that it had on his mental health.

While training with guide runners, he uses voice commands to interact with the glasses.

“If they say that’s Big Ben ahead of us I can just say ‘hey Meta take a picture,’” he said.

He said the hands free nature of the device is important.

“I don’t need to be worrying about fumbling with a mobile phone,” he said.

Smart glasses use a front facing camera to capture visual input and artificial intelligence to analyze it, converting the information into audio delivered through speakers built into the frame.

Chris Lewis, a technology analyst who is visually impaired and has used smart glasses while skiing, said the system provides an additional layer of awareness.

“The AI is taking the images coming in, analyzing it and giving you the information about what’s in front of you, what might be moving and what might be changing,” he said.

He said this allows users to receive information in real time without losing awareness of their surroundings, which is important for activities such as running.

However, Lewis said events like marathons can pose additional challenges, with large crowds putting pressure on mobile networks and potentially weakening signal, which in turn can affect how reliably the glasses deliver real time information.

Guide Dogs UK, which also provides other services to help people live independently, says the technology should be used alongside existing support systems rather than replacing them.

“These glasses can really support and enhance somebody’s independence but they’re not there to be relied upon or replace core independent skills,” said Tommy Dean, a technology specialist at the charity.

He said guide dogs, mobility training and human support remain essential, particularly in complex environments.

Ben Hatton, an analyst at CCS Insight who studies emerging consumer technologies, said reliability remains a key challenge.

“If you’re going to allow visually impaired people to walk down the street or cross busy roads with the technology then it has to be perfectly reliable every single time,” he said.

He said factors such as accuracy, connectivity and cost will determine how widely the technology can be adopted.

Despite those limitations, experts say advances in artificial intelligence are enabling mainstream devices to play a growing role in accessibility.

“The fact that consumer technology can enhance the experience of someone with a sight problem adds to the potential to be more and more independent,” Lewis said.

More than 59,000 runners are expected to take part in the London Marathon on Sunday, according to organizers, following a 26.2 mile route through the capital that starts in Greenwich and finishes near Buckingham Palace.



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US justice department drops probe into Fed chairman Jerome Powell

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US justice department drops probe into Fed chairman Jerome Powell


Powell’s term is nearing its end and the US Senate is considering Trump’s nominee for his replacement, Kevin Warsh. A key Republican, Thom Tillis, has withheld his support for Warsh unless the Trump administration would drop its investigation into Powell.



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Giants legend Lawrence Taylor, 67, hospitalized after medical emergency: report

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Giants legend Lawrence Taylor, 67, hospitalized after medical emergency: report


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Pro Football Hall of Famer Lawrence Taylor was hospitalized on Friday, TMZ reported.

The New York Giants legend suffered a medical emergency in New Jersey, warranting the visit, the outlet said.

Taylor’s status is unclear, but TMZ said that it does not appear to be serious, citing “those close to” him.

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Former New York Giant Lawrence Taylor attends a game between the Giants and the Indianapolis Colts at MetLife Stadium in East Rutherford, N.J., Jan. 1, 2023. (Jim McIsaac/Getty Images)

Taylor’s former Giants did not immediately respond to an email.

L.T. is widely regarded as the greatest linebacker to ever play. He was a three-time NFL Defensive Player of the Year, including in his rookie season.

He won two Super Bowls, made 10 straight Pro Bowls and was named the MVP of the 1986 season. He also remains the franchise’s all-time sacks leader, which includes his 9½ sacks from his rookie season before sacks became a stat.

Lawrence Taylor entering the field at MetLife Stadium before a game.

New York Giants legend Lawrence Taylor enters the field before a game against the Minnesota Vikings at MetLife Stadium in East Rutherford, N.J., Sept. 8, 2024. (John Jones/Imagn Images)

NEW YORK SPORTS RADIO HOSTS LOSE IT OVER CHAOTIC KNICKS, JETS, METS SCENES WITHIN A MINUTE OF EACH OTHER

This came despite a lavish lifestyle off the field, which resulted in legal troubles after his playing days. Drug problems have also resulted in health problems later in life.

Taylor showed his support for President Donald Trump in 2024, appearing at a rally in Wildwood, New Jersey.

“I grew up a Democrat, and I’ve always been a Democrat until I met this man right here,” Taylor said to cheers. “Nobody in my family ever will vote for a Democrat again.”

President Donald Trump and Lawrence Taylor standing in the Roosevelt Room of the White House

President Donald Trump and former New York Giants linebacker Lawrence Taylor attend an executive order signing ceremony in the Roosevelt Room of the White House in Washington, D.C., July 31, 2025. The order formally reestablishes the Presidential Fitness Test, creating school-based programs that reward excellence in physical education. (Eric Lee/Bloomberg)

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Taylor made Giants headlines last year when he quickly turned down Abdul Carter’s request to wear Taylor’s No. 56 that has been retired by the organization since 1994, one season after he retired.

Follow Fox News Digital’s sports coverage on X, and subscribe to the Fox News Sports Huddle newsletter.





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Dianna Russini deletes X account after intimate new Mike Vrabel photos surface

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Dianna Russini deletes X account after intimate new Mike Vrabel photos surface


Dianna Russini, the NFL reporter at the heart of a relationship scandal with New England Patriots coach Mike Vrabel, has deactivated her X account after intimate new photos of the pair surfaced Thursday.

Earlier this month, photos published by PageSix showed the pair holding hands at an Arizona resort. Both Russini, 43, and Vrabel, 50, are married to other people.

After initially downplaying the photos, Russini resigned from her post at The Athletic after the publication launched an investigation into her relationship with Vrabel. Meanwhile, Vrabel told the media Tuesday he has had “difficult conversations with people I care about.”

Since the scandal broke, Russini has faced relentless trolling on social media as sleuths have dug through her old posts and interviews about the Patriots coach.

Her decision to shut down her X account comes after PageSix published new photos appearing to show the pair kissing at a bar in New York City six years ago. An insider who took the photos told Page Six that they witnessed Russini’s legs “in between” Vrabel’s and that they were giving each other “a bunch of pecks constantly.”

Dianna Russini resigned from her position at ‘The Athletic’ over photos published showing her holding hands with Patriots head coach Mike Vrabel (Getty)
Russini has since deactivated her X account after relentless trolling over the scandal
Russini has since deactivated her X account after relentless trolling over the scandal (Getty)

Vrabel has been married to his wife, Jen, with whom he shares two children, since 1990, while Russini married Shake Shack executive Kevin Goldschmidt six months after the photos were reportedly taken in 2020. She and Goldschmidt also share two children.

Neither the Patriots nor Russini has responded to The Independent’s requests for comment.

On Thursday, Vrabel said he took accountability for creating a “distraction” for the NFL during the league’s draft week.

“I understand that there are questions. I take accountability for my actions, and the actions that caused a distraction to the people that I care most about — my family, this football team, the organization and our fans. My previous actions don’t meet the standard that I hold myself to. They don’t,” he told reporters.

The NFL has confirmed it is not investigating Vrabel’s conduct, with Commissioner Roger Goodell reiterating in an ESPN interview that the league views it as a “personal matter.”

Goodell added: “This is not a personal conduct policy as we know of today. It’s a personal matter and we’ll leave it at that. I think the teams handle these matters when they are personal matters. They have a lot more information that can benefit people involved.”

The Patriots has expressed its support for Vrabel’s decision. In a statement, the team said: “Mike has been open with us about his commitment to being the best version of himself for his family, this team and our fans, and we respect the steps he is taking to follow through on that commitment.”

Vrabel also confirmed he will not attend day three of the draft on Saturday to attend counseling.

In her resignation letter, Russini maintained that she covered the NFL “with professionalism and dedication.”

“I stand behind every story I have ever published,” she wrote.

Not long after Russini published her resignation letter, The Athletic executive editor Steven Ginsberg shared a statement with Page Six saying “there were clear concerns” when the first batch of photos surfaced, “but we received a detailed explanation and it was our instinct to support and defend a colleague while we continued to review the matter.”

However, “additional information emerged” and “new questions were raised that became part of our investigation,” he wrote.



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First-ever gene therapy for hearing loss gets FDA approval: ‘Groundbreaking’

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First-ever gene therapy for hearing loss gets FDA approval: ‘Groundbreaking’


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A new therapy for genetic hearing loss has just been approved by the Food and Drug Administration (FDA).

The treatment, Otarmeni (lunsotogene parvec-cwha), is the first-ever dual adeno-associated virus (AAV) vector-based gene therapy, meaning it uses two harmless viruses to deliver the therapy into cells.

In an FDA news release, the agency called the therapy “groundbreaking,” noting its potential to treat both pediatric and adult patients with “severe to profound” hearing loss linked to the OTOF gene.

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Positive results from drug trials were published in The New England Journal of Medicine in 2025, confirming that the gene therapy “improved hearing in patients with OTOF-related deafness, enabling natural acoustic hearing and normalizing hearing sensitivity in three of 12 treated patients.”

A new therapy for genetic hearing loss has just been approved by the Food and Drug Administration. (iStock)

The FDA approval marks the first disease-modifying treatment for OTOF-related deafness.

This is the sixth drug approval under the FDA commissioner’s National Priority Voucher (CNPV) pilot program and the first gene therapy to be approved through the initiative, according to the announcement.

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“Today’s approval is a significant milestone in the treatment of genetic hearing loss,” FDA Commissioner Marty Makary said in a statement.

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“Through the National Priority Voucher pilot program, the agency is accelerating therapies for rare diseases with unmet medical needs while proving we can successfully review even the most complex submissions — such as novel dual-vector gene therapies and combination products requiring coordination across multiple offices and centers — in significantly shortened time frames.”

Food and Drug Administration Commissioner Marty Makary speaking at a press conference with Secretary Robert F. Kennedy Jr. in Washington, D.C.

Food and Drug Administration Commissioner Marty Makary speaks during a news conference with Secretary of Health and Human Services Robert F. Kennedy Jr. at the Department of Health and Human Services in Washington, D.C., Oct. 29, 2025, discussing administration plans to lower drug costs. (Annabelle Gordon/Reuters)

Otarmeni is administered surgically as a one-time treatment, using a needle and a tiny tube to deliver the medicine directly into the inner ear (the cochlea) in both ears.

The therapy works by delivering a healthy copy of the OTOF gene to key cells in the inner ear, helping to restore the protein otoferlin so auditory signals can be sent to the brain, according to the FDA.

Woman getting ear exam

Side effects of Otarmeni may include middle ear infection, nausea, dizziness and procedural pain, according to the FDA. (iStock)

The treatment is intended for patients with preserved outer hair cell function and for those with no prior cochlear implant in the same ear. Side effects may include middle ear infection, nausea, dizziness and procedural pain.

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The FDA will host a public meeting June 4 to discuss program implementation, eligibility criteria and other processes for distribution, according to the announcement.



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